Manhyia Palace Museum in Kumasi served as the official residence of Asantehene Prempeh I following his return from exile in 1925. Built by the British after destroying the original Asante royal palace during the War of the Golden Stool, the building symbolizes resilience and royal restoration. In 1995, Otumfuo Opoku Ware II converted the palace into a museum to commemorate Asante rulers and preserve their cultural heritage.

Inside, visitors find life-sized wax effigies of Asante kings and queens; including Prempeh I, Prempeh II, Yaa Asantewaa, and the current Otumfuo Osei Tutu II as well as royal regalia, gold weights, ceremonial items, vintage furniture, the first television for the Asante Nation (from 1965), battle dresses, and photographic timelines of Asante history.

In 2024, the museum received a historic long-term loan of over 30 gold and silver artifacts from the British Museum, Victoria and Albert Museum, and Fowler Museum in Los Angeles items originally looted during the 1874 sacking of Kumasi and now displayed in Kumasi to reconnect the Asante with their heritage.